The thyrotropin receptor (or TSH receptor) is a receptor that responds to thyroid-stimulating hormone (“thyrotropin”) and stimulates the production of thyroxine (T4) and triiodothyronine (T3). Recombinatn human TSH allow to manipulate endocrine function of thyroid-derived cells, as part of the diagnosis and treatment of thyroid cancer. The TSH receptor is a member of the Glycoprotein hormone receptors family of integral membrane proteins. It is primarily present on the surface of the thyroid epithelial cells, but also appears on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease. HiTSeeker TSH Receptor cell line from Innoprot allows the measurement of the activity and potency of ligands; such as recombinant human TSH (rhTSH).
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