Vasoactive intestinal polypeptide receptor 1, aka VPAC1, encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. VPAC1 is present in several tissues; such as brain, lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis. VIP plays an imporatnt role in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. VIP acts in an autocrine fashion via VPAC1 to inhibit megakaryocyte proliferation and induce proplatelet formation. Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VPAC1. HiTSeeker VPAC1 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PACAP-38.
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