Human Adipose Microvascular Endothelial Cells

Human Adipose Microvascular endothelial cells line blood vessels and contribute to many biological processes; such as angiogenesis, coagulation, trafficking of lymphocytes, and the inflammatory response. Microvascular endothelial cells are diverse and have specific cellular characteristics and functions depending on the organ/tissue they are located. Adipose tissue is unique because it has the capacity to continually grow throughout adult life. It thus has a high occurrence of angiogenesis in order to provide the extensive vascularization require for adipose tissue. Studies have shown that angiogenesis precedes adipogenesis, implying that microvascular endothelial cells influence the proliferation of preadipocytes. Microvascular endothelial cell growth is at the same time stimulated by adipocyte secreted VEGG, suggesting a complex paracrine relationships between microvascular endothelial cells and preadipocytes during tissue development.