Human Nucleus Pulposus Cells

Reference: P10973

Human Nucleus Pulposus Cells

Human Nucleus Pulposus Cells (HNPC) provided by Innoprot are isolated from human healthy intervertebral disc. HNPC are cryopreserved at passage one and delivered frozen. Each vial of Human Nucleus Pulposus Cells contains more than 500.000 viable cells. They are guaranteed to further expand for 15 population doublings following the instructions provided in the technical sheet.

Innoprot also offers optimized medium and reagents for the growth of Human Nucleus Pulposus Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HNPC culture.


Size/Quantity: 500.000 Cells / vial


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Nucleus pulposus is the jelly-like substance in the middle of the intervertebral disc. It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of several components, such as collagen fibrils, proteoglycan aggrecans and nucleus pulposus cells. Nucleus pulposus cells reside in an environment that has a limited vascular supply and generate energy through anaerobic glycolysis. The cells synthesize collagen II and X; express hypoxia-inducible factor-1, and secrete interleukins-1, -6, and -10 and also granulocyte-macrophage colony-stimulating factor. Mechanical stress on nucleus pulposus cells promotes cell proliferation. Nucleus pulposus cells provide an in vitro model for the study of cellular and molecular events involved in disc degeneration, tissue engineering and cell therapy for spine disc disorders. Human Nucleus Pulposus Cells are also useful tools to stablish in vitro disease models for High Throughput and High Content Screening.



  • Reference: P10973
  • Size/Quantity: 5x105 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice