Human Perineurial Cells

Reference: P10357

Human Perineurial Cells

Human Perineurial Cells (HPNC) provided by Innoprot are isolated from human spinal nerve. HPNC are cryopreserved at passage one and delivered frozen. Each vial of Human Perineurial Cells contains more than 500.000 viable cells. They are guaranteed to further expand for 15 population doublings following the instructions provided in the technical sheet.

Innoprot also offers optimized medium and reagents for the growth of Human Perineurial Cells which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro HPNC culture.


Size/Quantity: 500.000 Cells / vial


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Perineurial cells are of mesenchymal origin and form the perineurium. The perineurium plays role in maintaining the integrity of the internal peripheral nerve environment by creating a physical barrier that; under physiologic condition limits the entry of biologically active proteins, infectious agents, and blood-borne cells into the nerve bundles. Human perineurial cells (PNC) comprise distinct ultrastructural features; such as non-branching thin cytoplasmic processes coated by an external lamina and joined at their ends by a tight junction, few organelles, actin and vimentin filaments, and numerous pinocytotic vesicles. PNC are initially recruited from the surrounding mesenchyme to form a loose, permeable sheath around axons and Schwann cells, where they are separated by the extracellular matrix. These cells later undergo a mesenchymal-to-epithelial transition to form tight junctions and organize into the perineurium. PNC are immunoreactive for vimentin and Glut-1 antigen but not for the Schwann cell marker S-100.

  • Reference: P10357
  • Size/Quantity: 5x105 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice

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