Immortalized Human Aortic Smooth Muscle Cells

Reference: P10456-IM

Immortalized Human Aortic Smooth Muscle Cells

Immortalized Human Aortic Smooth Muscle Cells (IM-HASMC) provided by Innoprot have been developed by immortalizing primary human healthy aortic smooth muscle cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of Immortalized Human Aortic Smooth Muscle Cells contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HASMC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HASMC culture.

1.950,00

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Smooth muscle cells (SMC) are primary contributors to the development of arterial disease. The ability of vascular SMC to switch to a proliferative phenotype is one of the main factors in the development and progression of vascular disease. Recent studies have demonstrated that SMC express calcium channels, ICAM-1, and VCAM-1. The expression of ICAM-1 and VCAM-1 on SMC may contribute to the inflammatory reaction in the vascular wall and may play an active role in the progression of vascular disease. Human Aortic Smooth Muscle Cells allows to perform in vitro assays in vascular disease research.

SMC are long and thin in structure and arrange around tissues in layers. They do not contain any sarcomeres and few nuclei but Myosin appears scattered throughout the cell. Dense-bodies attach to actin filaments in the muscle sarcoplasm, this prevents the actin molecules moving during contraction. The dense-bodies also connect other smooth muscle cells and appears arranged randomly throughout the fibres.

  • Reference: P10456
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only.
  • Shipping Conditions: Dry Ice