Immortalized Human Corneal Epithelial Cell Line

Reference: P10871-IM

Immortalized Human Corneal Epithelial Cell Line

Immortalized Human Corneal Epithelial Cell Line (IM-HCEpiC) provided by Innoprot have been developed by immortalizing primary human corneal epithelial cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 3th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of IM-HCEpiC contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HCEpC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HCEpiC culture.

 

Size/Quantity: 1 million cells / vial

1.950,00

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The cornea is a unique tissue due to its transparency and avascularity. The corneal epithelium plays a role in the innate immune response by sensing the presence of pathogens and providing signals to activate the corneal defense system. Corneal epithelial cells also express a high level of aldehyde dehydrogenase to protect them against UV- and 4-hydroxynonenal-induced cellular damage. The renewal of corneal epithelium depends on a a host of cytokines, including epidermal growth factor; which activates their cognate receptors in the deeper layers of the epithelium. Human corneal epithelial cells can be an alternative to animal testing in toxicology studies. They are also useful tools to understand the highly integrated balance between corneal epithelial proliferation, differentiation, and cell death. Immortalized Human Corneal Epithelial Cell Line also allow to stablish in vitro models for HIgh Throughput and High Content Screening.

  • Reference: P10871-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice