Immortalized Human Hepatic Stellate Cells

Reference: P10653-IM

Immortalized Human Hepatic Stellate Cells

Immortalized Human Hepatic Stellate Cells (IM-HHSteC) provided by Innoprot have been developed by immortalizing primary human healthy hepatic stellatat ceels wiyh SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of Immortalized Human Hepatic Stellate Cells contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HSteC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HSteC culture.


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Human Hepatic stellate cells (HSteC) are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, HSteC transform into myofibroblast-like cells; furthermore they are the major source of type I collagen in the fibrotic liver. Beyond these features, HSteC act as regulators of hepatic microcirculation via cell contraction, moreover in disease states, in the pathogenesis of intrahepatic portal hypertension. Proliferation and migration of HSteC and expression of chemokines play roles in the pathogenesis of liver inflammation and fibrogenesis. Immortalized Human Hepatic Stellate Cells are useful tools to understand the highly integrated balance between proliferation, differentiation, and cell death. This cell line also allow to stablish in vitro models for HIgh Throughput and High Content Screening.

  • Reference: P10653-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice