Immortalized Human Microglia

Reference: P10354-IM

Immortalized Human Microglia

Immortalized Human Microglia (IM-HM) provided by Innoprot have been developed by immortalizing primary human microglia with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. These primary cells go into senescence after the 2nd passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of Immortalized Human Microglia contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HM which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HM culture.

 

Size/Quantity: 1 million cells / vial

1.950,00

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Microglia is an important integral component of the neuro-glial cell network. They are present in the brain parenchyma from the early stage of development to the mature state. Microglia play an important role in brain immune surveillance. They can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells. They are also capable of Fc-mediated phagocytosis, and share many common antigens with hemopoietic and tissue macrophages. Upon activation, they act as brain macrophages to clear tissue debris, damaged cells, or microbes when programmed cell death occurs during brain development or when the CNS is injured. Immortalized Human Microglia Cell Line also allow to stablish in vitro models for HIgh Throughput and High Content Screening.

Furthermore, there is evidence that microglia are related in a variety of physiological and pathological processes in the brain through interaction with neurons and other glial cells. They also produce a variety of biologically active substances; such as growth factors and cytokines.

  • Reference: P10354-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice