Immortalized Human Renal Mesangial Cells

Reference: P10661-IM

Immortalized Human Renal Mesangial Cells

Immortalized Human Renal Mesangial Cells (IM-HRMC) provided by Innoprot have been developed by immortalizing primary human healthy renal mesangial cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of Immortalized Human Renal Mesangial Cells contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HRMC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HRMC culture.



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Renal mesangial cells are perivascular cells present within the central portion of the glomerular tuft between capillary loops. They have a variety of functions including synthesis and assembly of the mesangial matrix, endocytosis and processing of plasma macromolecules. Human Renal Mesangial Cells (HRMC) control of glomerular hemodynamics via mesangial cell contraction or release of vasoactive hormones. HRMC also synthesize, assemble and control turnover of the mesangial matrix. Matrix overproduction of mesangial cells occurs in various glomerular diseases, such as IgA nephropathy, mesangioproliferative glomerulonephritis, lupus nephritis, glomerulosclerosis and diabetic nephropathy. Immortalized Human Renal Mesangial Cells are an ideal model for studying mesangial injury and glomerular functions under both; physiological and pathophysiological conditions. Immortalized Human Renal Mesangial Cells are also useful tools to stablish in vitro disease models for High Throughput and High Content Screening.

  • Reference: P10661-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice