Mouse Microglia

Microglia, a key glial cell type in the central nervous system (CNS), play a crucial role in brain immune surveillance and homeostasis. Mouse Microglia are the primary innate immune effectors of the central nervous system. They present antigens via MHC class II to CD4+ T cells, perform Fc-mediated phagocytosis, and share antigens with hematopoietic and tissue macrophages. When activated, mouse microglia act as brain macrophages, clearing debris, damaged cells, and microbes. This occurs during brain development, programmed cell death, or CNS injury. They also influence brain function through interactions with neurons and other glial cells. By releasing growth factors and cytokines, they contribute to both normal and disease processes. Mouse microglia are a valuable tool for studying brain function and disease mechanisms. In vitro models using primary microglia help researchers investigate neuroinflammation, neurodegeneration, and potential therapeutic targets.