The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, is member of Alpha-1-adrenergic receptors (alpha-1-ARs) family. This gene encodes the alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants; which encode four different isoforms with distinct C-termini but having similar ligand binding properties. They activate mitogenic responses and regulate growth and proliferation of many cells. Gq/G11 family transducers mediates the primary transduction mechanism of this receptor, so calcium flux measurement allows to monitor receptor activation. MPXNOMAD α1A-adrenoceptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands, such as epinephrine.
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