The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is member of Alpha-1-adrenergic receptors (alpha-1-ARs) family. This gene encodes the alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. They activate mitogenic responses and regulate growth and proliferation of many cells. Gq/G11 family transducers mediates the primary transduction mechanism of this receptor, so calcium flux measurement allows to monitor receptor activation. Risperidone, an α1B-adrenoceptor antagonist, is an antipsychotic drug to treat schizophrenia, bipolar disorder, and irritability associated with autism. MPXNOMAD α1B-adrenoceptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands, such as epinephrine.
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