MPXNOMAD NTS1 Neurotensin Receptor Cell Line

Reference: P70746

MPXNOMAD NTS1 Neurotensin Receptor Cell Line

MPXNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and two Nomad Biosensors to monitor G-protein and β-arrestin modulation. Each vial of MPXNOMAD NTS1 Neurotensin Receptor Cell Line contains U2OS cells stably expressing the following constructs:

  • human NTS1 Neurotensin Receptor with no tag
  • Calcium Nomad Biosensor (Green Fluorescence)
  • β-arrestin Nomad Biosensor (Red Fluorescence)

MPXNOMAD NTS1 Neurotensin Receptor Cell Line allows to assay compounds analyzing both signalling pathways involving receptor activation; G protein by Ca2+ flux and β-arrestin recruitment, hence allowing biased activity studies. When an agonist binds to NTS1R a G protein is activated which, in turn, triggers a cellular response mediated by calcium and a subsequent internalization mediated by ß-Arrestin. This leads to an increase of fluorescence intensity of both β-Arrestin and Ca2+ biosensors. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.


Size/Quantity: 2 vials containing 3×106 cells / vial


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The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Neurotensin (NT) is a brain and gastrointestinal peptide. It fulfills a dual function of neurotransmitter or neuromodulator in the nervous system and of local hormone in the periphery. NTSR1 and NTSR2 genes contain seven transmembrane helices and are GPCRs. NTSR1 mediates multiple biological through modulation by neurotensin; such as low blood pressure, high blood sugar, low body temperature, antinociception, and regulation of intestinal motility and secretion. MPXNOMAD NTS1 Neurotensin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Neurotensin.

Click HERE to know more about NTSR1 Neurotensin Receptor.


  • Reference: P70746
  • Nomad Biosensors: β-arrestin & Ca++
  • Gene Bank Acc. Nº: AY429106
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice