Microglia, one of the glial cell types in the central nervous system (CNS), is an important integral component of the neuro-glial cell network. Microglia play an important role in brain immune surveillance. They can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells, and are capable of Fc-mediated phagocytosis, and share many common antigens with hemopoietic and tissue macrophages. Upon activation, they act as brain macrophages to clear tissue debris damaged cells, or microbes; when programmed cell death occurs during brain development or when the CNS is injured. Furthermore, there is evidence that microglia are important in a variety of physiological and pathological processes in the brain; through interaction with neurons, other glial cells, and production of biologically active substances such as growth factors and cytokines. Rat Microglia provide an invaluable tool for understanding physiological and pathophysiological relevance in brain function and disease.
Rat Microglia (RM) provided by Innoprot are isolated from postnatal day 2 rat brain. RM are cryopreserved immedaitelly after isolation and delivered frozen. Each vial of Rat Microglia contains more than 1 million viable cells. RM are guaranteed to further culture in the condition provided in the technical sheet; however, RM are not recommended for expanding or long-term cultures since the cells do not proliferate in regular culture
Innoprot also offers optimized medium and reagents for the growth of Rat Microglia which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro RM culture.
Size/Quantity: 1 million Cells / vial