Horse Dermal Fibroblasts

Cultures of Horse Dermal Fibroblasts are highly valuable for a broad range of cellular and molecular studies. This is mainly because fibroblasts are among the easiest cell types to maintain in vitro, and their robustness makes them suitable for diverse experimental manipulations ranging from studies employing gene transfection to microinjection. Fibroblasts secrete a nonrigid extracellular matrix that is rich in type I and/or type III collagen. There is evidence showing that fibroblasts in different organs are intrinsically different. Horse Dermal Fibroblasts are also capable of secreting significant amounts of hyaluronan, particularly in response to inflammatory stimuli, playing a role in modulating the local immune environment. During wound healing, dermal fibroblasts undergo a transition from a migratory, proliferative phenotype to a contractile, matrix-reorganizing phenotype, which is essential for proper tissue remodeling and scar formation.