ADORA2A gene encodes a protein which is one of receptor subtypes for adenosine, abundant in basal ganglia or vasculature. Activation of the adenosine A2A receptor by an agonist causes binding of Gs protein. Binding of Gs causes an adenylate cyclase stimulation and, therefore, an increase in the cAMP concentration. Adenosine A2A Receptor Assay from Innoprot…
ADORA2B gene encodes a protein which is one of receptor subtypes for adenosine, abundant in large intestine and bladder. A2B receptors plays an important role in mast cell activation, asthma, vasodilation, regulation of cell growth and intestinal function. Activation of the adenosine A2B receptor by an agonist causes binding of Gs protein. Binding of Gs…
The adenosine A3 receptor (ADORA3) is one member of the adenosine receptor group of GPCRs with adenosine as endogenous ligand. Activation of the adenosine A3 receptor by an agonist causes binding of Gi1/2/3 or Go protein. Binding of Gi1/2/3 causes an inhibition of adenylate cyclase and, therefore, a decrease in the cAMP concentration. Adenosine A3 Receptor…
The adenosine A1 receptor (ADORA1) is one member of the adenosine receptor group of GPCRs with adenosine as endogenous ligand. Activation of the adenosine A1 receptor by an agonist causes binding of Gi1/2/3 or Go protein. Binding of Gi1/2/3 causes an inhibition of adenylate cyclase and, therefore, a decrease in the cAMP concentration. Adenosine A1 Receptor…