publication

Article Published: Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor

Numerous studies have been published about the implication of the neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the pathogenesis of several neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis and motor neuron disease. BDNF activates the TrkB receptor with high potency and specificity, promoting neuronal survival, differentiation and synaptic plasticity.…

Detalles

El proyecto “Desarrollo de Modelos in vitro de enfermedad de Parkinson para el estudio de sus mecanismos moleculares y descubrimiento de nuevas terapias (SYNO)”, ha sido cofinanciado por el Gobierno Vasco y la Unión Europea

Innoprot ha recibido el apoyo del Gobierno Vasco y la Unión Europea a través del Fondo Europeo de Desarrollo Regional 2021-2027 (FEDER) para financiar el proyecto; “Desarrollo de Modelos in vitro de enfermedad de Parkinson para el estudio de sus mecanismos moleculares y descubrimiento de nuevas terapias (SYNO)” a través del programa HAZITEK 2022 (Proyecto…

Detalles

El proyecto “Plataforma para la detección rápida y fiable de virus basada en nanobodies y nanopartículas poliméricas” – HAZITEK P4V, recibe el apoyo de Gobierno Vasco a través del Fondo Europeo de Desarrollo Regional

El proyecto Plataforma para la detección rápida y fiable de virus basada en nanobodies y nanopartículas poliméricas – HAZITEK P4V, recibe el apoyo de Gobierno Vasco a través del Fondo Europeo de Desarrollo Regional Innoprot ha recibido el apoyo del Gobierno Vasco y la Unión Europea a través del Fondo Europeo de Desarrollo Regional 2021-2027…

Detalles
logo cells

Article Published: Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound

The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its potential use in long-term neuroprotective treatments. Here, we synthesized a doubly reduced DMC (DDMC) derivative with residual antibiotic activity and improved neuroprotective effects. The molecule was obtained by removal the dimethylamino substituent at…

Detalles
biomedicines

Article published: Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic p75NTR receptors. NGF has been shown to slow or prevent neurodegenerative signals in Alzheimer’s Disease (AD) progression. However, its low bioavailability and its…

Detalles

El proyecto SYNO “Desarrollo de modelos in vitro de la Enfermedad de Parkinson para el estudio de sus mecanismos moleculares y descubrimiento de nuevas terapias”, ha sido cofinanciado por la Diputación de Bizkaia con cofinanciación de Fondos FEDER

El proyecto “SYNO – Desarrollo de modelos in vitro de la enfermedad de parkinson para el estudio de sus mecanismos moleculares y descubrimiento de nuevas terapias” de expediente 6/12/2I/2021/28 ha sido financiado por la Diputación Foral de Bizkaia dentro del Plan 2i 2021 y cuenta con cofinanciación del FEDER. Bizkaiko Foru Alundiak finantziatu du proiektu…

Detalles

Article published: Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out

The UV-nanoimprint lithography(UV-NIL) fabrication of a novel network of micron-sized channels, forming an open channel microfluidic system is described. Details about the complete manufacturing process, from mastering to fabrication in small batches and in high throughput with up to 1200 micro titer plates per hour is presented. Deep insight into the evaluation of a suitable…

Detalles
Scientific Reports

Article published: Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models

Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological consequences of cardiovascular and renal damage. We aimed to design chemical NGAL inhibitors and investigate its effects in experimental models of myocardial infarction (MI) and chronic kidney disease induced by 5/6 nephrectomy (CKD) on respectively 8-12 weeks…

Detalles