D3 Dopamine Receptor Internalization Assay from Innoprot allows to assay compounds, or analyze their capability to modulate DRD3 receptor activation and the following redistribution process inside the cells. When a ligand binds to the DRD3, it activates a G protein, which internalizes in big and high intensity vesicles. This assay has been validated measuring Fluorescent DRD3 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring D3 Dopamine Receptor redistribution process in High Throughput Screening.
Assay: Dopamine Receptors