The urotensin-2 receptor, also known GPR14 is a class A rhodopsin family GPCR that is 386 amino acids long. It binds primarily to the neuropeptide urotensin II. UT receptor is present in the myocardium, and smooth muscle cells and endothelial cells of arteries and veins. Expression levels of UT receptor mRNA are high in the atrium of rats with congestive heart failure resulting from coronary artery ligation, but also in the atrium, ventricle, and aorta of Spontaneously Hypertensive Rats. In the kidney, UT receptor is present in the renal tubular cells and vascular endothelial cells. Functions of the urotensin II receptor may play roles in cardiomyocitic hypertrophy, stress, and REM sleep. HiTSeeker Urotensin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as UT-2.
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