Immortalized Human Cardiac Fibroblasts

Reference: P10453-IM

Immortalized Human Cardiac Fibroblasts

Immortalized Human Cardiac Fibroblasts (IM-HCF) provided by Innoprot have been developed by immortalizing primary human cardiac fibroblasts with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of IM-HCF contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HCF which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HCF culture.


Size/Quantity: 1 million cells / vial


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Cardiac fibroblasts (CF) are the principal cell type of the heart. They provide structural support for cardiac myocytes, are a source of paracrine growth factors, and are an important cellular component of the myocardial response to injury. CF are responsible for extracellular matrix synthesis in the heart during development and pathological conditions. Their proliferation and matrix synthesis is essential for scar formation at sites of myocardial infarction or cardiac fibrosis. CF also respond to changes in microenvironments in pathological conditions by modulating integrin expression. Human Cardiac Fibroblasts culture allows to study the cardiac matrix remodeling by physiological (exercise) and pathological (hypertension) stressors. Immortalized Human Cardiac Fibroblasts also allow to stablish in vitro models for HIgh Throughput and High Content Screening.

  • Reference: P10453-IM
  • Size/Quantity: 1x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice