Immortalized Human Retinal Astrocytes

Reference: P10259-IM

2.085,00€

Immortalized Human Retinal Astrocytes (IM-HRA) provided by Innoprot have been developed by immortalizing primary human retinal astrocytes with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of Immortalized Human Retinal Astrocytes contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HRA which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HRA culture.

Size/Quantity: 1 million Cells / vial

Astrocytes are the major cell type and among the most functionally diverse group of cells in the mammalian brain. They provide a variety of supportive functions to their partner neurons in the central nervous system (CNS); such as neuronal guidance during development, and nutritional and metabolic support throughout life. Human Astrocytes play important roles in various pathological processes. Impairment of normal astrocyte functions during stroke and other insults can critically influence neuron survival. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is also related to astrocyte surface molecule expression and trophic factor release. Much of what we have learned about astrocytes is from in vitro studies and astrocyte culture is a useful tool for exploring the diverse properties of this cell type. Human Retinal Astrocytes are also very useful cells to stablish disease models for High Throughput and Hight Content Screening.