Immortalized Human Synoviocytes

Reference: P10972-IM

2.085,00€

Immortalized Human Synoviocytes (IM-HS) provided by Innoprot have been developed by immortalizing primary human synoviocytes isolated from healthy human synovial tissue with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 5th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of Immortalized Human Synoviocytes contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HS which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HS culture.

Size/Quantity: 1 million cells / vial

Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. They form a distinct structure called the synovial lining layer. Synoviocytes produce synovial fluid, are responsible for absorption from the joint cavity and are also in control of blood/synovial fluid exchanges. Synoviocytes proliferate, show anchorage-independent growth, and secrete a variety of effector molecules that promote inflammation and joint destruction. In addition, they are part of a complex network of autocrine and paracrine acting factors. Immortalized Human Synoviocytes provide new insight into synovial tissue organization and morphogenesis and are a potential therapeutic targe. They are also useful tools to stablish in vitro disease models for High Throughput and High Content Screening.