A novel family of GPCR cell lines have been developed through stable transfection with different fluorescent Nomad reporter genes to monitor b-arrestin recruitment in combination with Ca++ increase measurement, allowing a multiplex funcitonal assay to characterize GPCR activation pathways and identify directly GPCR biased ligands.
Each cell line is stably transfected with a label-free GPCR, the Nomad b-arrestin reporter gene and the Nomad Ca++ reporter gene. These recently launched cell lines have been validated with reference agonists in High Throughput Screening.
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