Fluorescent FPR2/ALX Formylpeptide Receptor

Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line - Imagen 2

Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line

Reference: P30276

6.950,00€

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line contains U2OS cells stably expressing FPR2/ALX tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line allows to assay compounds, or analyze their capability to modulate FPR2/ALX activation and the following redistribution process inside the cells. When a ligand binds to the FPR2/ALX Formylpeptide Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent FPR2/ALX redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring FPR2/ALX Formylpeptide Receptor redistribution process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×10⁶ cells / vial

The formyl peptide receptors (FPRs) are GPCRs that transduce chemotactic signals in phagocytes. They mediate host-defense as well as inflammatory responses including cell adhesion, migration, granule release and superoxide production. The FPR2 receptor is present on human neutrophils, eosinophils, monocytes, macrophages, T cells, synovial fibroblasts, and intestinal and airway epithelium. FPR2 is also known as the LXA4 or ALX/FPR2 receptor based on studies finding that is a high affinity receptor for the arachidonic acid metabolite, lipoxin A4 (LXA4), and thereafter for a related arachidonic acid metabolite, the Epi-lipoxin, aspirin-triggered lipoxin A4 (i.e. ATL, 15-epi-LXA4) and a docosahexaenoic acid metabolite, resolvin D1 (i.e. RvD1); these three cell-derived fatty acid metabolites act to inhibit and resolve inflammatory responses. Green Fluorescent FPR2/ALX Formylpeptide Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as WKYMVm.

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Reference: P30276
DNA Accession Number: AY225226
Size/Quantity: 2 vials containing 3x10⁶ cells / vial
Product Use: For research use only
Shipping Conditions: Dry Ice

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