Green Fluorescent B2 Bradykinin Receptor Cell Line

Reference: P30210

Green Fluorescent B2 Bradykinin Receptor Cell Line

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent B2 Bradykinin Receptor Cell Line contains CHO-K1 cells stably expressing BDKRB2 tagged with tGFP.  These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent B2 Bradykinin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate BDKRB2 activation and the following redistribution process inside the cells. When a ligand binds to the BDKRB2, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent BDKRB2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring B2 Bradykinin Receptor redistribution process in High Throughput Screening.


Size/Quantity: 2 vials containing 3×106 cells / vial


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The bradykinin receptor family is a group of G-protein receptors whose principal ligand is the protein bradykinin. This gene encodes a receptor for bradykinin B2. The 9 aa bradykinin peptide elicits many responses such as vasodilation, edema, smooth muscle spasm and pain fiber stimulation. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Green Fluorescent B2 Bradykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as bradykinin.

Click HERE to know more about Bradykinin Receptor B2.

  • Reference: P30210
  • DNA Accesion Number: NM_000623
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice