The bradykinin receptor family is a group of G-protein receptors whose principal ligand is the protein bradykinin. This gene encodes a receptor for bradykinin B2. The 9 aa bradykinin peptide elicits many responses such as vasodilation, edema, smooth muscle spasm and pain fiber stimulation. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Green Fluorescent B2 Bradykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as bradykinin.
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