Immortalized Human Pancreatic Microvascular Endothelial Cells

Immortalized Human Pancreatic Microvascular Endothelial Cells

Reference: P10473-IM

2.085,00€

Immortalized Human Pancreatic Microvascular Endothelial Cells (IM-HPanMEC) provided by Innoprot have been developed by immortalizing primary human pancreatic microvascular endothelial cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 4th passage while the SV40‐tranduced cells go beyond 30 passages.

Each vial of IM-HPanMEC contains more than 1 million viable cells. Innoprot also offers optimized medium and reagents for the growth of IM-HPanMEC which are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HPanMEC culture.

Size/Quantity: 1 million Cells / vial

The pancreas is an endocrine gland and digestive organ which secretes hormones and produces pancreatic juice to aid in digestion. Pancreatic endocrine cells, aka pancreatic islets, produce vital hormones such as glucagon, insulin, amylin, and somatostatin. In order to support the islets, the pancreas is a highly vascularized organ where endothelial cells play a critical role. Human Pancreatic microvascular endothelial cells (HPanMEC) not only function to transport oxygen and nutrients to the pancreas, but also affect beta cell function and proliferation, influence insulin gene expression during islet development, and produce various growth factors associated with vasoactivity. Additionally, PanMEC participate in optimizing blood glucose sensing and regulation. PanMEC play an important role in the development and progression of pancreatic cancer. Immortalized Human Pancreatic Microvascular Endothelial Cells are a useful in vitro model for studying islet biology, pancreatic cancer, transplantation, and regenerative medicine.