Neurite Outgrowth & Mitosis Assay Cell Line

Neurite outgrowth is a key process during neurogenesis. During development, neurons extend numerous processes that differentiate into dendrites and axons. These processes, also termed neurites, are critical for communication between neurons.  The initiation of neurite protrusion and subsequent elongation involves complex intracellular signaling. Neurites are particularly interesting in relation to neuropathological disorders, neuronal injury/regeneration, and neuropharmacologic research and screening. Neurite Outgrowth & Mitosis Assay Cell Line allows the analysis of neurites while monitoring the cellular mitosis level through microtubule structural changes. The growth of neurites in human neurons is a critical event in neuronal development; formation and remodelling of synapses, response to injury, and regeneration. Many neuroscience projects are focused on identifying new drugs that affect this event. The discovery of new compounds that can positively affect neuritogenesis are very important for developing new therapeutics against both neurodegenerative diseases and injury. Measurement of neurite outgrowth using an automated image-based assay can be of use in the research; screening and validation phases of the drug discovery process.