Dopamine receptor D2, a.k.a. D2R, is a protein that, in humans, is encoded by the DRD2 gene. The dopamine D2 receptor is the main receptor for most antipsychotic drugs. Most of the older antipsychotic drugs; such as chlorpromazine and haloperidol are antagonists for the dopamine D2 receptor, but are, in general, very unselective. In similar manner, older dopamine agonists used for Parkinson’s disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another; and, although most of these agents do act as D2 agonists, they affect other subtypes as well. Several selective D2 ligands are, however, now available, and this number is likely to increase as further research progresses. cAMPNOMAD D2 Dopamine Receptor Cell Line allows the measurement of the activity of ligands, such as Dopamine.
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