cAMPNOMAD D2 Dopamine Receptor Cell Line

Reference: P70518

cAMPNOMAD D2 Dopamine Receptor Cell Line

cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of cAMPNOMAD D2 Dopamine Receptor Cell Line contains U2OS cells stably expressing the following constructs:

  • human D2 Dopamine Receptor (DRD2) with no tag
  • cAMP Nomad Biosensor (Red Fluorescence)

cAMPNOMAD DRD2 Cell Line allows to assay compounds analyzing the G-Protein signalling pathway by Go involving receptor activation. When an agonist binds to DRD2, the Go protein is activated which, in turn, triggers a cellular response mediated by cAMP. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.

Size/Quantity: 2 vials containing 3×106 cells / vial


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Dopamine receptor D2, a.k.a. D2R, is a protein that, in humans, is encoded by the DRD2 gene. The dopamine D2 receptor is the main receptor for most antipsychotic drugs. Most of the older antipsychotic drugs; such as chlorpromazine and haloperidol are antagonists for the dopamine D2 receptor, but are, in general, very unselective. In similar manner, older dopamine agonists used for Parkinson’s disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another; and, although most of these agents do act as D2 agonists, they affect other subtypes as well. Several selective D2 ligands are, however, now available, and this number is likely to increase as further research progresses. cAMPNOMAD D2 Dopamine Receptor Cell Line allows the measurement of the activity of ligands, such as Dopamine.

Click HERE to know more about DRD2 Receptor.


  • Reference: P70518
  • Nomad Biosensors: cAMP
  • GeneBank Accesion Number: NM000794
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice