9.995,00€
cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of cAMPNOMAD HTR1A Receptor Cell Line contains HEK293 cells stably expressing the following constructs:
cAMPNOMAD HTR1A Receptor Cell Line allows to assay compounds analyzing the G-Protein signalling pathway via Gi/o protein activation. When an agonist binds to HTR1A, Gi/o protein is activated which, in turn, triggers a cellular response mediated by cAMP. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified in living cells in a dose-response manner by fluorescence emission in a microplate reader.
Size/Quantity: 2 vials containing 3×106 cells / vial
The 5-hydroxytryptamine receptor 1A (HTR1A), known as the serotonin 1A receptor, is a GPCR with serotonin as its endogenous ligand. Upon activation by an agonist, HTR1A couples primarily to Gi/o proteins. This inhibits adenylate cyclase activity, leading to a reduction in intracellular cAMP levels.
The HTR1A receptor is widely expressed in the central nervous system, particularly in brain regions such as the hippocampus, cortex, and raphe nuclei. It regulates mood, anxiety, and stress, making it a key target in neuropsychiatric research and drug development.
Click HERE to know more about HTR1A Receptor.
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