alpha-synuclein stable Cell lines

Reference: P30707-02

alpha-synuclein stable Cell lines

A novel family of stable cell lines have been developed through stable transfection with different fluorescent-α-synuclein. TagGFP2 and tRFP- α-synuclein cell lines are stably-transfected and it is ready to use in cell-based assay applications. These stably transfected cell linew provide consistent levels of expression, which helps to simplify the interpretation of the results. These cell lines are intended to be used as an “in vitro” models for research studies.

 

Cell Lines available

  • SH-SY5Y cell line stably expressing green fluorescent alpha – synuclein
  • SH-SY5Y cell line stably expressing red fluorescent alpha – synuclein
  • HEK293 cell line stably expressing green fluorescent alpha – synuclein
  • HEK293 cell line stably expressing red fluorescent alpha – synuclein
  • U2OS cell line stably expressing green fluorescent alpha – synuclein

All vials of the different stable cell line contains 3 million cells. It is guaranteed that these cells will expand in vitro following the cell culture manual

2.950,00

Clear

Alpha-synuclein (also α-synuclein) is a protein whose function in the healthy brain is currently unknown. It is abundant in the brain but also appear smaller amounts in the heart, muscles, and other tissues. In the brain, alpha-synuclein appears mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. Innoprot has developed a family of fluorescent alpha-synuclein stable Cell lines for cell-based assays applications.

Alpha-synuclein is specifically upregulated in a discrete population of presynaptic terminals of the brain during a period of acquisition-related synaptic rearrangement. Alpha-synuclein significantly interacts with tubulin, and that alpha-synuclein may have activity as a potential microtubule-associated protein, like tau. The aggregation, deposition, and dysfunction of alpha-synuclein are common events in neurodegenerative disorders, also called synucleinopathies. These include Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Study of alpha-synuclein is crucial to test the emerging hypothesis that Parkinson’s disease affects many areas of the central nervous system beyond the substantia nigra, and even extends beyond the boundaries of the central nervous system. Different cell lines, including HEK293, U2OS and SH-SY5Y stably expressing green and red fluorescent α-synuclein are available at Innoprot.

  • Reference: P30707-02
  • Size/Quantity: 1 vial containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice