<sub>cAMP</sub>NOMAD DP1 Receptor Cell Line
<sub>cAMP</sub>NOMAD DP1 Receptor Cell Line - Image 2
<sub>cAMP</sub>NOMAD DP1 Receptor Cell Line - Image 3

cAMPNOMAD DP1 Receptor Cell Line

Reference: P70532

9.995,00€

cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation via cAMP release. Each vial of cAMPNOMAD DP1 Receptor Cell Line contains U2OS cells stably expressing the following constructs:

  • Human Prostaglandin D2 receptor 1 (DP1) with no tag
  • cAMP Nomad Biosensor (Green Fluorescence)

cAMPNOMAD DP1 Receptor Cell Line allows to assay compounds analyzing the G-Protein signalling pathway via cAMP production upon receptor activation. When an agonist binds to DP1, a G protein is activated, triggering a cellular response mediated by cAMP. This leads to an increase in green fluorescence intensity of cAMP biosensor. The activity can be easily quantified in living cells in a dose-response manner by fluorescence emission in a microplate reader.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

The prostaglandin D2 receptor 1 (DP1), also known as PTGDR, is a G protein-coupled receptor (GPCR). It binds primarily to prostaglandin D2 (PGD2), with prostaglandin E2 (PGE2) acting as a secondary ligand. These two lipid mediators have been demonstrated to be involved in the processes of allergic inflammation, asthma, and immune regulation. Upon activation, DP1 stimulates adenylate cyclase via trimeric Gs proteins, leading to increased intracellular cAMP levels. cAMPNOMAD DP1 Receptor Cell Line from Innoprot enables the measurement of the activity and potency of ligands, such as PGE2.

cAMPNOMAD DP1 Receptor Cell Line also expresses Green Fluorescent cAMP Nomad Biosensor. This allows monitoring cAMP concentration changes when receptor is activated/inhibited.

Click HERE to know more about DP1 Receptor.
  • Reference: P70532
  • Nomad Biosensors: cAMP
  • GenBank Accesion Number: NM_000953
  • Size/Quantity: 2 vials containing 3x10⁶ cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice

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