HiTSeeker Adenosine A2B Receptor Cell Line comprises HEK293 cells stably expressing ADORA2B.
ADORA2B gene encodes a protein which is one of receptor subtypes for adenosine, abundant in large intestine and bladder. A2B receptors plays an important role in mast cell activation, asthma, vasodilation, regulation of cell growth and intestinal function. The presence of a HIF-1alpha binding site in the promoter region of the A2b receptor gene implicates the receptor in hypoxia and angiogenesis. Targeting the A2b receptor may also be useful in combating autoimmune type I diabetes.
Adenosine A2B Receptor have multiple binding partners that modulate ADORA2B responses and functions; these include netrin-1, E3KARPP-EZRIN-PKA, SNARE, NF-B1/P105, and -actinin-1. Netrin-1, the neuronal guidance molecule, induced during hypoxia, reduces inflammation by activating ADORA2B, which inhibit neutrophils migration. SNARE protein interacting with ADORA2B, mostly that located inside the cell, recruits the receptor to the plasma membrane following agonist binding. After this interaction, a multiprotein complex with E3KARP (NHERF2) and ezrin stabilizes ADORA2B in the plasma membrane.