HiTSeeker LPA3 Lysophospholipid Receptor Cell Line

Reference: P30156

HiTSeeker LPA3 Lysophospholipid Receptor Cell Line

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker LPA3 Lysophospholipid Receptor Cell Line contains U2OS cells stably expressing LPA3 Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker LPA3 Lysophospholipid Receptor Cell Line allows to assay compounds, or analyze their capability to modulate LPA3 receptor. When a ligand binds to the LPA3R, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker LPA3 Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with LPA. The high reproducibility of this assay allows monitoring LPA3 Receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×106 cells / vial


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Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycerol-3-phosphate) is a phospholipid that plays roles in numerous normal physiological and pathological processes; such as brain development, blood vessel formation, embryo implantation, hair growth, neuropathic pain, lung fibrosis and colon cancer. Among the LPA receptors, LPA3 is unique in that a specific form of LPA (2-acyl LPA with unsaturated fatty acids) activates it. It is also present in a limited number of tissues such as the reproductive organs. LPA3-mediated LPA signaling is essential for proper embryo implantation. HiTSeeker LPA3 Lysophospholipid Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as LPA.

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  • Reference: P30156
  • Size/Quantity: 2 vials containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice