Angiogenesis is critical for many physiological processes including organ development, tissue repair, and the female reproductive tract. Human endometrial microvascular endothelial cells (HEMEC) are present in the inner mucous membrane of the uterus aka the endometrium. HEMEC play role in endometrial angiogenesis during the menstrual cycle with the rapid growth and shedding of the endometrium. Angiogenesis in the endometrium occurs through the non-sprouting mechanisms intussusception and vessel elongation. Studies have indicated that elevated HEMEC proliferation in the endometrium can lead to disorders such as endometriosis and menorrhagia. Cultured HEMEC are a useful model to elucidate the mechanisms of normal and pathological angiogenesis and develop treatments for female reproductive tract disorders.
Human EMEC are a useful in vitro model to elucidate the mechanisms of angiogenesis and to develop treatments for female reproductive tract disorders. Human Endometrial Microvascular Endothelial Cells are also useful tools to develop disease models for High Throughput and High Content Screening.