Immortalized Human Conjunctival Epithelial Cell Line

Human conjunctiva is a translucent membrane that lines the inner surface of the eyelids and covers the sclera. Its coverage comprises two layers of stratified, non-keratinized conjunctival epithelial cells (ConEpiC). Human Conjunctival Epithelial Cell Line is different than the corneal epithelium by a specific expression profile of keratins. ConEpiC coverage comprises mucin-rich glycocalyx, which has differente functions; such as promotion of tear adherence, prevention of pathogen penetrance, and provision of lubrication. Decrease or loss of mucin/glycocalyx production generates squamous metaplasia, which may lead to dry eye and ocular surface diseases. ConEpiC also respond to histamine by stimulating phosphatidylinositol turnover and secreting cytokines, and as a result may be a good target when developing topical ocular drugs to treat allergic conjunctivitis. Immortalized Human Conjunctival Epithelial Cell Line also allow to stablish in vitro models for HIgh Throughput and High Content Screening.