Green Fluorescent NK3 Tachykinin Receptor Cell Line
Green Fluorescent NK3 Tachykinin Receptor Cell Line - Image 2
Green Fluorescent NK3 Tachykinin Receptor Cell Line - Image 3
Green Fluorescent NK3 Tachykinin Receptor Cell Line - Image 4

Green Fluorescent NK3 Tachykinin Receptor Cell Line

Reference: P30230

6.950,00€

Green Fluorescent GPCR cell lines from Innoprot allows to perform GPCR internalization assays. Each vial of Green Fluorescent NK3 Tachykinin Receptor Cell Line contains SH-SY5Y cells stably expressing NK3 Receptor tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual.

Innoprot Green Fluorescent NK3 Tachykinin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate NK3 Receptor activation and the following redistribution process inside the cells. When a ligand binds to the NK3 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent NK3 Receptor redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring NK3 Receptor redistribution process in High Throughput Screening.

 

Size/Quantity: 2 vials containing 3×106 cells / vial

The tachykinin receptor NK3 (TACR3) also known as neurokinin 3 receptor (NK3R)  is a GPCR. This gene encodes the receptor for the tachykinin neurokinin 3, also known to as neurokinin B; although it has some affinity for other tachykinins. The protein is the product of the TACR3 gene. A number of selective ligands are available for NK3. NK3 receptor antagonists are under development as treatments for various indications, such as treatment of  sex-hormone related disorders or antipsychotic drug. Green Fluorescent NK3 Tachykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Substance P.

Click HERE to know more about NK3 Receptor.
  • Reference: P30230
  • DNA Accession Number: NM_001059
  • Size/Quantity: 2 vials containing 3x10⁶ cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice

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