HiTSeeker beta-2 adrenergic receptor Cell Line

Reference: P30125

5.250,00€

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker beta-2 adrenergic receptor Cell Line contains HEK293 cells stably expressing ADRB2 with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker ADRB2 Cell Line allows to assay compounds, or analyze their capability to modulate ADRB2. When a ligand binds to the ADRB2, it activates a G protein, which in turn, triggers a cellular response mediated by cAMP. HiTSeeker ADRB2 cell line has been validated measuring cAMP concentration changes in the cytosol upon activation with Isoproterenol. The high reproducibility of this assay allows monitoring ADRB2 receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×10⁶ cells / vial

The beta-2 adrenergic receptor (β2 adrenoreceptor); also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor. It interacts with (binds) epinephrine; a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increased cAMP, and downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. HiTSeeker beta-2 adrenergic receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as isoproterenol.

Reference: P30125
Size/Quantity: 2 vials containing 3x10⁶ cells / vial
Product Use: For research use only
Shipping Conditions: Dry Ice

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