HiTSeeker beta-3 adrenergic receptor Cell Line

Reference: P30101

5.250,00€

HiTSeeker are cell lines stably expressing label-free GPCRs, also known as seven-(pass)-transmembrane domain receptors. Each vial of HiTSeeker beta-3 adrenergic receptor Cell Line contains HEK293 cells stably expressing ADRB3 with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual.

Innoprot HiTSeeker ADRB3 Cell Line allows to assay compounds, or analyze their capability to modulate ADRB3. When a ligand binds to the ADRB3, it activates a G protein, which in turn, triggers a cellular response mediated by cAMP. HiTSeeker ADRB3 cell line has been validated measuring cAMP concentration changes in the cytosol upon activation with isoproterenol. The high reproducibility of this assay allows monitoring ADRB3 receptor activation process in High Throughput Screening.

Size/Quantity: 2 vials containing 3×10⁶ cells / vial

The beta-3 adrenergic receptor (β3 adrenoreceptor); also known as ADRB3, is a cell membrane-spanning beta-adrenergic receptor. It appears mainly in adipose tissue and plays an important role in the regulation of lipolysis and thermogenesis. Some β3 agonists show antistress effects in animal studies, suggesting it also has a role in the central nervous system (CNS). β3 receptors also appear in the gallbladder, urinary bladder, and in brown adipose tissue. Their role in gallbladder physiology is unknown, but they play a role in lipolysis and thermogenesis in brown fat. In the urinary bladder it causes relaxation of the bladder and prevention of urination. HiTSeeker beta-3 adrenergic receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as isoproterenol.

Reference: P30101
Size/Quantity: 2 vials containing 3x10⁶ cells / vial
Product Use: For research use only
Shipping Conditions: Dry Ice

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