The tachykinin receptor NK2 (TACR2) also known as neurokinin 2 receptor (NK2R) is a GPCR. This gene encodes the receptor for the tachykinin neuropeptide substance K; also referred to as neurokinin A, although it has some affinity for other tachykinins. The protein is the product of the TACR2 gene. Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant. HiTSeeker NK2 Tachykinin Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as Substance P.
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