Fluorescent Nuclear Localization Signal Cell Line

Nuclear transport is a mechanism that needs specific controls to decide when a protein enters or leaves the nucleus. A series of proteins responsible for nuclear transport are in charge of the translocation of material between the cytoplasm and the nucleus. Importin protein family is in charge of the protein translocation from the cytoplasm to the nucleus guided by NLS signals. Nuclear localization signals (NLS) are short peptide sequences within the amino acid sequence of nuclear cargo proteins. Commonly, the NLS sequences contain a high proportion of lysine (K) or arginine (R) aminoacids and are very similar to the first found NLS sequence in the simian virus SV40 (PKKKRKV). Fluorescent Nuclear Localization Signal Cell Line from is a useful tool to study the translocation processes between nucleus and cytoplasm. In the therapeutic area, nuclear targeting via NLS tagging is useful in cancer therapy; and it is also helping to improve the DNA vaccines delivery into the cell nucleus.