Name: <sub>cAMP</sub>NOMAD VPAC2 Receptor Cell Line
SKU: 4045
Price: 9995.00 EUR
Availability: InStock

_cAMPNOMAD VPAC2 Receptor Cell Line

_cAMPNOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of _cAMPNOMAD VPAC2 Receptor Cell Line contains U2OS cells stably expressing the following constructs:

human VIP Receptor 2 (VPAC2R) with no tag
cAMP Nomad Biosensor (Red Fluorescence)

_cAMPNOMAD VPAC2 Receptor Cell Line allows to assay compounds analyzing the G-Protein signalling pathway by Gs involving receptor activation. When an agonist binds to PACAP-38, the Gs protein is activated which, in turn, triggers a cellular response mediated by cAMP via adenylate cyclase stimulation. This leads to an increase of red fluorescence intensity of cAMP biosensor. So, the activity can be easily quantified on living cells in a dose-response manner by fluorescence emission in a microplate reader.

Size/Quantity: 2 vials containing 3×10⁶ cells / vial

9.995,00€

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Vasoactive intestinal polypeptide receptor 2, aka VPAC2, encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. VPAC2 Receptor is present throughout the body and is also present in a variety of human neoplastic tissues. VPAC2 may play a role in schizophrenia, and the the abnormal expression of VIPR2 messenger RNA in gallbladder tissue may play a role in the formation of gall stones and polyps. _cAMPNOMAD VPAC2 Receptor Cell Line from Innoprot allows the measurement of the activity and potency of ligands; such as PACAP-38.

Click HERE to know more about VPAC2 Receptor.